Now more than ever, mission-critical data centers require strong reliability and resilience. Indoor air quality plays a vital role in keeping server racks and electronic components fully operational. Poor air quality caused by particulate and gaseous contaminants from indoor sources and outdoor ventilation can lead to downtime and productivity loss. This session outlines filtration requirements for particles and molecules, and explains how air quality standards differ across hyperscale, mission-critical, enterprise, and edge data centers to ensure optimal performance.